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Phase 2 study. For more information, visit www.allegroeye.com. ALG-1007 (Allegro Ophthalmics, San Juan Capistrano, CA, USA) is a topical application of risuteganib, a small peptide integrin regulator that modulates multiple integrin subunits, including integrin αM and β2, the subunits involved in complement 3 inflammatory pathways. [ 11, 12] Gene expression studies have demonstrated reduced gene level of integrin αM and β2 submits in mice retina treated with risuteganib. ALG 1007, a peptide integrin inhibitor is being developed by Allegro Ophthalmics for the treatment of dry eye disease (DED).

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CHICAGO, IL — October 16, 2014 — Allegro Ophthalmics, LLC, dedicated to establishing integrin peptide therapy as the next-generation pharmaceutical category for the treatment of vitreoretinal diseases, today announced that it is enrolling patients in a Phase 2 trial that will evaluate the safety and efficacy of Luminate®, previously known as ALG-1001, in patients with diabetic macular edema (DME). ALG-1007.

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proof-of-concept clinical trial for the treatment of dry eye disease (DED) will be presented during the 37 th Congress of the Allegro’s other ophthalmology assets include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease, which is currently in phase 2 development outside the United States. ALG-1007 is a topical integrin regulator in development for potential use in patients with dry eye disease. ALG-1007 demonstrated a strong signal in an ex-U.S. proof-of-concept clinical trial in which it showed a dose-response curve and that it was generally well-tolerated.

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2019-05-17 Expanding its integrin-regulating portfolio, Allegro has developed ALG-1007 for topical use in dry eye disease. ALG-1007 demonstrated promising results in an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a second and larger ex-U.S. Phase 2 study. For more information, visit www.allegroeye.com. About Bausch + Lomb Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. It is currently in Phase 2 development outside the United States.

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A second and larger ex-U.S.

proof-of-concept study in humans, and is currently being evaluated in a second and larger ex-U.S.
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proof-of-concept trial with ALG-1007 for dry eye At its highest dose concentration (0.6%), the new investigational topical drug ALG-1007 (Allegro Ophthalmics) had statistically significant efficacy in nearly all assessments for dry eye and a more rapid onset of action compared to the lowest dose (0.125%), according to a company press release. ALG-1007 (Allegro Ophthalmics, San Juan Ca pistrano, CA, USA) is a topical applica tion of risuteganib, a small peptide . integrin regulator that m odulates multiple in tegrin subunits, 2019-04-25 · Allegro Ophthalmics has added ALG-1007, a new anti-integrin drug candidate for the treatment of dry eye disease, to its portfolio, the company announced in a press release.The topical agent is Today, Allegro also announced that the results of its ALG-1007 ex-U.S. proof-of-concept clinical trial for the treatment of dry eye disease (DED) will be presented during the 37 th Congress of the Allegro’s other ophthalmology assets include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease, which is currently in phase 2 development outside the United States.

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It is currently in Phase 2 development outside the United States. The Option payment totaling $50 million would be made in two tranches, with the first payment of $10 million upon signing. Allegro’s other ophthalmology assets include ALG-1007, a topical integrin regulator candidate for the treatment of dry eye disease. The candidate is in Phase II development outside the US. 2019-05-14 · Allegro Ophthalmics, LLC, a privately held biopharmaceutical company focused on the development of novel anti-integrin therapies for the treatment of ocular diseases, today announced positive results of an ex-U.S. proof-of-concept clinical trial of the new investigational ALG-1007 topical drop drug candidate in patients with dry eye disease (DED). “Allegro is excited to share our ex-U.S. proof-of-concept data of ALG-1007 for dry eye disease,” said Vicken Karageozian, M.D., President and CEO of Allegro Ophthalmics.

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